Preparation and Antimicrobial Studies of Pyrazolo-Thiazole Fused Heterocyclic Compounds

Published in Journal

Anusandhan (RNTUJ-AN) [RNTUJ-AN] (Vol:17/ Issue: 26) DOI: [NA]
Authors: Nunna G Ramesh Babu1 Sheetal Gulati2 H.S.Patel3
Subjects: Science Technology and Management

Year: March.2021
Volume: 17 / Issue: 26
Pages: 2378-2381
Publisher: ANUSANDHAN(RNTUJ-AN)
Source:
ISSN: 2278-4187
E-ISSN: 2457-0656
DOI: NA
Published URL:
Published On: March.2021

Article Details

Preparation and Antimicrobial Studies of Pyrazolo-Thiazole Fused Heterocyclic Compounds | Original Article

Nunna G Ramesh Babu1 Sheetal Gulati2 H.S.Patel3 in Anusandhan (RNTUJ-AN) | Multidisciplinary Academic Research

ABSTRACT:

ABSTRACT

2-[5-(4-Ary)furan-2-y]-3-(4H-1,2,4-triazol-4-yl)thiazolidin-4-one (Ia-e) compounds [1] reacted with furfural in the presence of sodium hydroxide affords, 5-[(furan-2-yl)methylen]-2-[5-(4-alkylphenyl)furan-2-y]-3-(4H-1,2,4-triazol-4-yl)thiazolidin-4-one (IIIa-e). These (IIIa-e) compounds reacted with Isoniazide yield [3-(furan-2-yl)-5-[5-(4-alkylphenyl)furan-2-yl]-6-(4H-1,2,4-triazol-4-yl)3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazol-2-yl](pyridin-4-yl) methanone (IVa-e). The molecular structures of all these novel heterocyclic derivatives were confirmed by elemental content and FTIR-NMR spectral features. The antimicrobial activity of all these derivatives were monitored.